In 1906, the room was described as "a large rectangular room, occupying the whole of the right wing of the house and lighted by windows on three sides. The walls are white, with panels of red silk damask encased within molded frames. The curtains are of the same materials. The rich cornice supports a ceiling elaborately detailed in low relief in decorated panels. At the further end, as one enters the room from the gallery, is the mantel of white marble with mottled yellow columns... The room is so large that it affords ample space for much furniture, and it contains a host of rare, curious and beautiful objects... The further end of the room opens directly on to the semicircular piazza at the end of the house." Barr Ferree, "Notable American Homes: 'The Homestead', the Home of Nathaniel Thayer, Esq. Lancaster, Massachusetts." American Homes and Gardens, 1906.
Two of Nathaniel Thayer's daughters were married at the Homestead. Cornelia Van Renssaeler Thayer and Count Carl von Moltke of Denmark were married in 1907. Their wedding was reported by the New York Times as an important society event. Sarah Barroll Thayer and Frederick Winthrop said their vows before the marble fireplace in the Red Room in 1911. Their wedding was a small, family affair due to the death of her father only two months earlier.
NOTE: The north windows and part of the semicircular piazza were displaced by storage rooms after the college purchased the building.